Description

Buy Geftinat 250 mg Online

Geftinat 250 mg Tablet is an anticancer medication which is utilized in the treatment of malignant growth of the lungs. It should just be utilized under the supervision of a certified doctor. This drug isn’t suggested for use in patients with lung and liver ailments.

Gefitinib is utilized for the treatment of privately progressed or metastatic non-little cell lung disease.

Gefitinib may likewise be recommended for different conditions as dictated by the specialist.

What is geftinat 250 mg?

Geftinat 250mg Tablet soothes the outrageous torment and inconvenience endured by patients of bosom or lung malignant growths. It hinders the generation of disease cells, along these lines restraining the spread of the dangerous tissues. It tends to be regulated orally with or without sustenance.

The measurements relies on the therapeutic history of the patient, wellbeing conditions and the reaction to the treatment.

The medication is contraindicated in patients who have experienced or are enduring glaucoma, cardiovascular clutters, lungs or liver issue or renal failing. Take appropriate therapeutic assistance on the off chance that you are pregnant, arranging a pregnancy at any point in the near future or breastfeeding. You should likewise advise the specialist regarding whatever other doctor prescribed medications that you might take, for example, hormonal pills as oral contraceptives, or any dietary enhancements as Geftinat 250mg Tablet may connect with different medications and cause various wellbeing inconveniences.

You should maintain a strategic distance from liquor utilization, smoking, tobacco or caffeine over the span of the treatment to stay away from any further wellbeing entanglements. There might be various symptoms, for example, migraines, obscured vision, some queasiness, and some unfavorably susceptible rashes on the skin. Anyway there can be some unfriendly responses also. It is exhorted that even the smallest uneasiness ought to be accounted for to the specialist promptly, so as to keep away from intricacies.

How To Geftinat 250 mg Work?

Geftinat tablets 250mg contain gefitinib an intense inhibitor of tyrosine kinase (TK), a compound that phosphorylates a protein inside a cell (moves a phosphate from ATP to a protein inside the cell), which is the manner in which numerous cell procedures are managed.

Tyrosine kinases (TK) are cell surface receptors for some, cell delivery people including development factors and gefitinib in Geftinat tablets 250mg goes about as an intense inhibitor of the Epidermal Growth Factor receptor (EGFR) by focusing on the piece of the receptor where EGF ties to ATP (adenosine triphosphate).

EGF invigorates cell development, expansion and separation in typical cells. It acts by authoritative with high proclivity to its cell surface receptor EGFR, which has a place with the TK group of receptors.

At the point when EGF ties to EGFR, the receptor experiences a shape change, which enacts TK movement by phosphorylation of its substrates inside the phone and this is the initial phase in a mind boggling cell flagging pathway associated with cell expansion and survival. Ordinarily EGFR enactment is managed and along these lines, cell multiplication is controlled and customized cell passing (apoptosis) happens.

In any case, the transformation related with NSCLC leaves the receptor in an express that is continually initiated or turned on (constitutively actuated) notwithstanding when EGF isn’t bound to the receptor. This outcomes in cells that are animated to continually multiply and endure prompting NSCLC.

Regularly the declaration of ECGFR is communicated at low levels yet over articulation can cause malignant growth and is related with forceful progressed and metastatic tumors as is found in 40-80% of NSCLC4.

There are a few distinctive quality transformations that can influence the control of EGFR action and gefitinib in Geftinat tablets 250mg is best in tumors containing the Exon 19 cancellation or a L858R change, which is point transformations influencing a solitary DNA nucleotide. It has been recommended that distinguishing proof of explicit changes in the ECGFR quality may foresee affectability to gefitinib5,6.

There is additionally proof of enhancement of the particular transformed enacting quality now and again of NSCLC and this is thought to present expanded helplessness to gefitinib in Geftinat tablets 250mg1. Gefitinib in Geftinat tablets 250mg works by obstructing the intracellular phosphorylation of EGFR, which hinders the flagging pathway for cell expansion and survival and actuates cell demise in NSCLC cells, which results in tumor relapse.

How To Take Geftinat 250 mg Tablet?

You should take your Geftinat tablets 250mg swallowed whole with a glass of water once daily with or without food.  The dose you take and for how long depends on your doctor’s recommendation and you should continue to take your Geftinat tablets 250mg for as long as recommended by your doctor.

Drug interaction of Geftinat 250 mg

Interaction with Alcohol

  • Description – Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Instructions – Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

The drugs that interact with Gefitinib are:

  • Acetaminophen
  • Carbamazepine
  • Chloramphenicol
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Indinavir
  • Ketoconazole
  • Leflunomide
  • Lomitapide
  • Mipomersen
  • Omeprazole
  • Ranitidine
  • Warfarin

Side Effects of Geftinat 250 mg

  • Abdominal pain
  • Diarrhoea
  • Fatigue
  • Fever
  • Headache
  • Loss of appetite
  • Eye irritation
  • Blurred vision
  • Clay-coloured stools
  • Discolouration of urine
  • Skin rash

Geftinat 250 mg Dosage

  • Missed Dose

Take the missed dose as soon as you remember. Skip the missed dose if the time remaining for your next dose is less than 12 hours. Do not double your dose to make up for the missed dose.

  • Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

Warning of Geftinat 250 mg tablet

Skin reactions – Patients receiving Geftinat 250 mg Tablet have experienced severe skin reactions like toxic epidermal necrolysis, Stevens Johnson syndrome, and erythema multiforme. Close monitoring of symptoms like change in color of the skin, skin rashes, itching, blistering, etc. is necessary while receiving this medicine. Any such symptoms should be reported to the doctor on priority. The treatment should be discontinued if these symptoms appear.

Pregnancy – This medicine is not recommended for use in pregnant women.

Breast-feeding – This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If this medicine is prescribed, your doctor will advise you to discontinue breastfeeding.

Precaution of Geftinat 250 mg tablet

  • are allergic to gefitinib or any ingredients in Geftinat
  • are pregnant or are breastfeeding
  • have kidney or liver disease
  • have a history of eye pain or inflammation
  • have gastrointestinal problems particularly diarrhoea as this can worsen with Geftinat
  • have lung problems like pneumonia or interstitial lung disease

are taking medicines that interact with Geftinat, including corticosteroids and NSAIDs for pain and inflammation, anticoagulants like warfarin, the beta blocker metoprolol, verapamil for hypertension, proton pump inhibitors like omeprazole, antifungals like ketoconazole, antibiotics like ciprofloxacin, erythromycin, clarithromycin, rifampicin, anticonvulsants like phenytoin, carbamazepine, ranitidine for reflux.

If you have an allergy to gefitinib or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are pregnant or may be pregnant. If you are breast-feeding.

Storage Conditions for Geftinat 250 mg

Store Geftinat 250mg tablet in a cool and dry place (Not in refrigerator).

 Do not leave it in the car. Heat and dampness can destroy some medicines.

Keep this cancer medicine away from the reach of children or pets. A locked cupboard at least one-and-a-half meters above the ground is a good place to store medicines.

Keep your medicine in the original container until it is time to take them.

 Do not store Geftinat 250mg or any other medicine in the bathroom or near the kitchen sink.

Additional information

Equivalent Brand

Gleevec

Indication

Anti Cancer

Strength

Imatinib (100mg)

Manufacturer

Cipla Ltd

Pharmaceutical Form

Tablets

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